Article Text

PDF
Bilateral coordination of gait and Parkinson’s disease: the effects of dual tasking
  1. M Plotnik1,2,
  2. N Giladi1,3,
  3. J M Hausdorff1,4,5
  1. 1
    Movement Disorders Unit and Laboratory for Gait and Neurodynamics, Department of Neurology, Tel-Aviv Sourasky Medical Centre, Tel-Aviv, Israel
  2. 2
    The Gonda Brain Research Center, Bar Ilan University, Ramat Gan, Israel
  3. 3
    Department of Neurology, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel
  4. 4
    Department of Physical Therapy, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel
  5. 5
    Division on Aging, Harvard Medical School, Boston, Massachusetts, USA
  1. Dr M Plotnik, Laboratory for Gait and Neurodynamics, Movement Disorders Unit, Tel-Aviv Sourasky Medical Center, 6 Weizmann St., Tel-Aviv, 64239, Israel; meirp{at}tasmc.health.gov.il

Abstract

The aetiology of gait disturbances in Parkinson’s disease (PD) is not fully understood. Recently, it was shown that in patients with PD, bilateral coordination of gait is impaired and that walking while being simultaneously engaged in a cognitive task is detrimental to their gait. To assess whether cognitive function influences the bilateral coordination of gait in PD, this study quantified left–right stepping coordination using a phase coordination index (PCI) that evaluates both the variability and inaccuracy of the left–right stepping phase (φ) generation (where the ideal φ value between left and right stepping is 180°). This report calculated PCI values from data obtained from force sensitive insoles embedded in subjects’ shoes during 2 min of walking in a group of patients with PD (n = 21) and in an age matched control group (n = 13). All subjects walked under two walking conditions: usual walking and dual tasking (DT) (ie, cognitive loading) condition. For patients with PD, PCI values were significantly higher (ie, poorer coordination) during the DT walking condition compared with usual walking (p<0.001). In contrast, DT did not significantly affect the PCI of the healthy controls (p = 0.29). PCI changes caused by DT were significantly correlated with changes in gait variability but not with changes in gait asymmetry that resulted from the DT condition. These changes were also associated with performance on a test of executive function. The present findings suggest that in patients with PD, cognitive resources are used in order to maintain consistent and accurate alternations in left–right stepping.

Statistics from Altmetric.com

Footnotes

  • Competing interests: None.

  • Funding: This work was supported in part by the Inheritance Fund of the Israeli Ministry of Health, NIH grants AG-14100, RR-13622, HD-39838 and AG-08812, by the US-Israel Bi-National Science Foundation, by the Parkinson’s Disease Foundation (PDF), New York, USA, and the National Parkinson Foundation (NPF), Miami, USA and by the European Commission in the context of FP6 projects DAPHNet, FET-018474-2, and SENSACTION-AAL, INFSO-IST-045622.

  • Ethics approval: The experimental protocols were approved by the Human Studies Committee of the Tel Aviv Sourasky Medical Centre.

  • See Editorial Commentary, p 247

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Linked Articles