J Neurol Neurosurg Psychiatry 80:429-431 doi:10.1136/jnnp.2007.142349
  • Short report

Disrupted intrinsic functional connectivity in the vegetative state

  1. F Cauda1,2,
  2. B M Micon3,
  3. K Sacco1,2,
  4. S Duca1,
  5. F D’Agata1,2,4,
  6. G Geminiani1,2,
  7. S Canavero3
  1. 1
    CCS fMRI, Koelliker Hospital, Torino, Italy
  2. 2
    Department of Psychology, University of Turin, Torino, Italy
  3. 3
    Turin Advanced Neuromodulation Group, Torino, Italy
  4. 4
    Department of Neuroscience, Molinette Hospital, Torino, Italy
  1. Dr F Cauda, Dipartimento di Psicologia, Via Po 14, 10123 Torino, Italy; franco.cauda{at}
  • Received 12 December 2007
  • Revised 2 July 2008
  • Accepted 10 July 2008


It is debatable as to whether the spontaneous blood-oxygen-level dependent fluctuations that are observed in the resting brain in turn reflect consciously directed mental activity or, alternatively, constitute an intrinsic property of functional brain organisation persisting in the absence of consciousness. This report shows for the first time, in three patients, that the persistent vegetative state (PVS) is marked by a dysfunctional default mode network, with decreased connectivity in several brain regions, including the dorsolateral prefrontal cortex and anterior cingulated cortex, especially in the right hemisphere. This finding supports the view that the resting state is involved in self-consciousness, and that the right-hemisphere default state may play a major role in conscious processes. It is speculated that the default state may act as a surrogate marker of PVS with awareness contents and, therefore, could replace a more complex activation paradigm.


  • Competing interests: None.

  • Ethics approval: Ethics approval was provided by the Ethical Committee of the Department of Psychology, University of Turin.

  • Patient consent: Obtained.

  • ▸ Additional online materials and methods are published online only at

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