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Folic acid supplementation: too much of a good thing?
  1. W Allen Hauser
  1. Professor W Allen Hauser, College of Physicians and Surgeons and Mailman School of Public Health, Columbia University, 630 W 168th St, New York, New York 10032, USA; wahauser{at}optonline.net

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Morrow and colleagues1 report on the association of folate use and major malformations in women with epilepsy (see page 506).1 The data, derived from their prospective study of pregnancy outcomes in women with epilepsy, suggests that high dose folate supplementation provides no benefit for prevention of congenital malformations in offspring of women with epilepsy (WWE).

Offspring of women with epilepsy exposed to antiseizure medications, particularly valproate2 or carbamazepine,3 have an increased risk for …

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