Table 2 Relation of amyloid plaques, neurofibrillary tangles and neuropil threads with memory, language and abstract/visuospatial
performance over time in the epidemiological sample
| CA1 | Subiculum | EC | |||||||
| Plaques | Tangles | Threads | Plaques | Tangles | Threads | Plaques | Tangles | Threads | |
| Estimated β (SE) | Estimated β (SE) | Estimated β (SE) | Estimated β (SE) | Estimated β (SE) | Estimated β (SE) | Estimated β (SE) | Estimated β (SE) | Estimated β (SE) | |
| Memory performance | |||||||||
| Time | −2.44 (3.21) | 6.19 (3.27) | −1.79 (3.29) | −2.99 (3.13) | 4.14 (2.91) | −1.49 (3.27) | −0.77 (3.78) | −3.73 (6.38) | 3.05 (4.65) |
| Autopsy group | −2.84 (18.15) | −35.21 (31.11) | −15.06 (17.88) | −11.34 (20.19) | −38.28 (29.27) | −20.34 (16.14) | −27.66 (17.81) | 18.98 (16.65) | −33.02 (20.07) |
| Time×autopsy group | −15.49 (6.70)* | −15.39 (4.10)* | −10.99 (3.31)* | −24.52 (10.29)* | −13.48 (3.94)* | −12.55 (3.52)* | −7.54 (4.37)* | 1.25 (7.26) | −9.67 (4.96)* |
| Abstract/visuospatial performance | |||||||||
| Time | −0.82 (1.51) | 1.51 (1.20) | −0.45 (1.55) | 0.28 (1.50) | 0.28 (1.50) | −0.08 (1.51) | −0.74 (1.68) | 0.45 (2.63) | 2.35 (1.23) |
| Autopsy group | −14.60 (10.95) | −20.45 (15.35) | −26.02 (8.60)* | −7.14 (14.86) | −7.14 (14.86) | −7.26 (16.09) | −20.65 (9.14)* | 4.27 (8.97) | −6.62 (12.43) |
| Time×autopsy group | 4.80 (2.41)* | −2.61 (2.26) | 3.20 (3.68) | −5.52 (2.34)* | −5.52 (2.34)* | 0.11 (4.35) | 0.52 (3.81) | −0.52 (3.07) | −5.10 (2.22)* |
| Language performance | |||||||||
| Time | −0.31 (0.61) | 0.69 (0.50) | −0.46 (0.55) | −0.95 (0.63) | −0.72 (0.50) | −0.37 (0.57) | −0.76 (0.50) | 0.67 (0.89) | 0.56 (0.49) |
| Autopsy group | −1.56 (3.67) | −7.83 (2.04)* | −6.35 (2.41)* | 0.63 (3.37) | −8.72 (2.61)* | −3.79 (2.76) | −7.35 (1.95)* | −5.14 (3.46) | −6.43 (2.40)* |
| Time×autopsy group | 1.29 (1.83) | −1.05 (0.50)* | 2.71 (1.86) | −3.69 (1.49)* | 0.62 (0.70) | 1.49 (1.95) | 2.27 (1.63) | −0.89 (1.02) | −0.82 (0.68) |
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All models are adjusted for age, sex and apolipoprotein E genotype.
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*Significant at a 0.05 level.
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β, regression coefficient; SE, standard error.
