J Neurol Neurosurg Psychiatry 80:1019-1022 doi:10.1136/jnnp.2008.170027
  • Research paper

Prestroke physical activity and early functional status after stroke

  1. N Stroud1,
  2. T M L Mazwi1,
  3. L D Case2,
  4. R D Brown, Jr3,
  5. T G Brott1,
  6. B B Worrall4,
  7. J F Meschia1,
  8. for the Ischemic Stroke Genetics Study Investigators
  1. 1
    Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA
  2. 2
    The Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA
  3. 3
    The Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA
  4. 4
    Department of Neurology, University of Virginia, Charlottesville, Virginia, USA
  1. Correspondence to Dr J F Meschia, Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA; meschia.james{at}
  • Received 9 December 2008
  • Revised 18 March 2009
  • Accepted 29 March 2009
  • Published Online First 14 July 2009


Background: The importance of physical activity as a modifiable risk factor for stroke in particular and cardiovascular disease in general is well documented. The effect of exercise on stroke severity and stroke outcomes is less clear. This study aimed to assess that effect.

Methods: Data collected for patients enrolled in the Ischemic Stroke Genetics Study were reviewed for prestroke self-reported levels of activity and four measures of stroke outcome assessed at enrolment and approximately 3 months after enrolment. Logistic regression was used to assess the association between physical activity and stroke outcomes, unadjusted and adjusted for patient characteristics.

Results: A total of 673 patients were enrolled; 50.5% reported aerobic physical activity less than once a week, 28.5% reported aerobic physical activity one to three times weekly, and 21% reported aerobic physical activity four times a week or more. Patients with moderate and high levels of physical activity were more likely to have higher Barthel Index (BI) scores at enrolment. A similar association was detected for exercise and good outcomes for the Oxford Handicap Scale (OHS). After 3 months of follow-up, moderate activity was still associated with a high BI score. No significant association was detected for activity and the OHS or Glasgow Outcome Scale at follow-up after adjustment for patient characteristics.

Conclusions: Higher levels of self-reported prestroke physical activity may be associated with functional advantages after stroke. Our findings should be seen as exploratory, requiring confirmation, ideally in a longitudinal study of exercise in an older population.


  • Funding The Ischemic Stroke Genetics Study (ISGS) was supported by a grant from the NINDS (NINDS R01 NS42733; JFM, principal investigator).

  • Competing interests None.

  • See Editorial Commentary, p 942

  • Ethics approval Ethics approval was provided by the Institutional Review Boards governing Mayo Clinic (Rochester, Minnesota and Jackson, Florida), Emory University School of Medicine (Atlanta, Georgia), the University of Florida/Shands Hospital (Jacksonville, Florida), the University of Virginia (Charlottesville, Virginia) and Wake Forest University School of Medicine (Winston-Salem, North Carolina).

  • Patient consent Obtained.

  • Statistical analysis was conducted by LDC, Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest University School of Medicine.

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