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Late-onset cervicoscapular muscle atrophy and weakness after radiotherapy for Hodgkin disease: a case series
  1. A Furby1,
  2. A Béhin2,
  3. J-P Lefaucheur3,
  4. K Beauvais1,
  5. P Marcorelles4,
  6. J-M Mussini5,
  7. G Bassez3,
  8. A Créange3,
  9. B Eymard2,
  10. I Pénisson-Besnier5
  1. 1
    Unité de Neurophysiologie Clinique, Hôpital Yves Le Foll, Saint-Brieuc, France
  2. 2
    Centre de référence des maladies rares neuromusculaires, APHP, GH Pitié-Salpêtrière, Paris, France
  3. 3
    Centre de référence des maladies rares neuromusculaires, APHP, GH Henri Mondor—Albert Chenevier, Créteil, France
  4. 4
    Pôle de Biologie Pathologie, Hôpital Morvan, CHU Brest, Brest, France
  5. 5
    Centre de référence des maladies neuromusculaires Nantes-Angers, CHU d’Angers et Nantes, Angers, France
  1. Correspondence to Dr A Furby, Unité de Neurophysiologie Clinique, Hôpital Yves Le Foll, 22 027 Saint-Brieuc, France; alain.furby{at}ch-stbrieuc.fr

Abstract

Patients with cervical or mediastinal Hodgkin disease (HD) classically underwent chemotherapy plus extended-field radiation therapy. We report six patients who gradually developed severe atrophy and weakness of cervical paraspinal and shoulder girdle muscles 5–30 years after mantle irradiation for HD. Although clinical presentation was uniform, including a dropped head syndrome, electrophysiological and pathological findings were rather heterogeneous. Either neurogenic or myogenic processes may be involved and sometimes combined. We discuss the pathophysiological mechanisms underlying these cervicoscapular motor complications of mantle irradiation in HD.

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Footnotes

  • Competing interests None.

  • Patient consent Obtained.

  • Provenance and Peer review Not commissioned; externally peer reviewed.

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