Statistics from Altmetric.com
Of the neurodegenerative disorders, prion diseases pose some unique challenges. The phenotypic spectrum is sufficiently diverse that this diagnosis will not infrequently intrude as a consideration, with the attendant risk of inadvertent disease transmission during healthcare provision adding concerns not extant in relation to most neurological diseases, especially disorders such as Alzheimer's disease. Prompt, accurate diagnosis can assist in pre-empting and thereby minimising transmission risk, while serving to avoid unhelpful investigations and treatments, and facilitate more informed prognostication. Notwithstanding the acknowledged need to continue searching for improvements in our diagnostic capacity, there has fortunately been major progress over the last 10–15 years in relation to the premortem diagnosis of sporadic Creutzfeldt–Jakob disease (sCJD), the most common form of human prion disease. In addition to the more recent contribution of brain MRI,1 the recognition that 14-3-3 protein detection in …
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.