Background Distal sensory polyneuropathy (DSP) is a well-known complication both of advanced HIV disease and of antiretroviral treatments (ARTs), in particular stavudine and didanosone. Both are widely used in sub-Saharan Africa. There are few data documenting the prevalence of HIV DSP in African settings.
Aim To describe the prevalence of DSP among Tanzanian patients with HIV, on and off ART and with CD4 counts above and below 200×106/l. We recruited HIV-positive clinic attendees into four groups: >6 months ART exposure and (i) CD4<200 cells/μl or (ii) CD4>200 cells/μl; ART naïve and (iii) CD4<200 cells/μl or (iv) CD4>200 cells/μl. Primary outcome was DSP as defined by presence of at least one symptom and one clinical sign elicited with the ACTG screening tool for DSP.
Results 335 subjects were recruited. Nine were excluded. Subject numbers were 81 (ART<200), 78 ART/>200), 81 (noART/<200) and 86 (noART/>200). Prevalences of DSP in each group were ((ART/<200) 43.2% (CI 33.7 to 55.5)), ((ART/>200) 41.3% (% CI 30.5 to 53.5)). ((noART/<200) 33.3% (% CI 22.8 to 43.8)) and ((noART/>200) 20.9% (% CI 12.0 to 29.4)).
Conclusion HIV DSP is frequently present even amongst otherwise largely asymptomatic patients. Stavudine and didanosone expose HIV patients to an avoidable risk of DSP with significant morbidity and an impaired quality of life. Diagnosis and management of DSP is inadequate. Access to nonneurotoxic ART regimes as well as earlier diagnosis and initiation of ART is needed.
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.