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Roll on genetics of PARK and Parkinsonism in the developing world
  1. Raj N Kalaria,
  2. Rufus Akinyemi
  1. Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
  1. Correspondence to Professor Raj N Kalaria, Institute for Ageing and Health, Wolfson Research Centre, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK; r.n.kalaria{at}ncl.ac.uk

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Ageing-related Parkinsonian syndromes and dementias with parkinsonism are recognised worldwide. However, knowledge on monogenic inheritance or genetics of these neurodegenerative disorders is meagre from the developing world.1 The remarkable progress within the last decade in the genetics of Parkinson's disease (PD) and disorders exhibiting parkinsonism has provided an impetus for genetic screening of these syndromes in different indigenous populations.2 Since the recognition of the α-synuclein gene, a staggering 15 PARK loci have been ascribed to autosomal dominant and recessive forms of PD (http://www.pdgene.org). In addition, mutations in unpredictably divergent genes such as the microtubule associated protein tau, glucocerebrosidase, PANK2 and PLA2G6 are attributed to parkinsonism in variants of …

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