Background Focal spasticity is a significant motor disorder following stroke, and Botulinum Toxin Type-A (BoNT-A) is a useful treatment for this. The authors evaluated kinematic modifications induced by spasticity, and whether or not there is any improvement following injection of BoNT-A.
Methods Eight patients with stroke with upper-limb spasticity, showing a flexor pattern, were evaluated using kinematics before and after focal treatment with BoNT-A. A group of sex- and age-matched normal volunteers acted as a control group.
Results Repeated-measures ANOVA showed that patients with stroke performed more slowly than the control group. Following treatment with BoNT-A, there was a significant improvement in kinematics in patients with stroke, while in the control group, performance remained unchanged.
Conclusions Focal treatment of spasticity with BoNT-A leads to an adaptive change in the upper limb of patients with spastic stroke.
- upper limb
- Botulinum Toxin
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Funding The work was supported in part by the National Institute for Neurological Disorders and Stroke (NINDS) Intramural Program and the Institute for Neurological Research-FLENI.
Competing interests None.
Ethics approval Ethics approval was provided by the Institute for Neurological Research-FLENI-IRB.
Patient consent Obtained.
Provenance and peer review Not commissioned; externally peer reviewed.