Article Text

PDF
Pretreatment tumoural perfusion correlates with an imaging-based response to dexamethasone in patients with glioblastoma multiforme
  1. Paul A Armitage1,
  2. Chris Schwindack1,
  3. Mark E Bastin2,
  4. Ian R Whittle1
  1. 1Clinical Neurosciences, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK
  2. 2Medical and Radiological Sciences (Medical Physics), School of Clinical Sciences and Community Health, University of Edinburgh, Western General Hospital, Edinburgh, UK
  1. Correspondence to Dr Paul A Armitage, Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK; paul.armitage{at}ed.ac.uk

Abstract

Imaging-based markers of treatment response are increasingly being used in studies of brain-tumour therapies, for evaluating novel treatments and further understanding of existing therapies. An ultimate goal of these studies is to identify pre- or early-stage treatment imaging biomarkers that enable prediction of subsequent treatment response. We hypothesised that pretreatment MRI-based measurements of tumoural perfusion may provide a suitable imaging-based biomarker for prediction of subsequent treatment response and evaluated this in a group of nine high-grade glioma patients undergoing dexamethasone treatment. A strong positive correlation was observed between tumoural blood flow (R2=0.90, p<0.001) and tumoural blood volume (R2=0.76, p=0.002), and subsequent treatment response as measured by alterations in tumour leakage properties. These preliminary results indicate that measurements of tumoural perfusion may provide useful imaging biomarkers for predicting treatment response to dexamethasone and would therefore also be worth evaluating in newer emerging therapies.

  • Tumoural perfusion
  • MRI
  • dexamethasone
  • glioblastoma multiforme
  • imaging biomarkers
  • neurooncology
  • pharmacokinetics
  • tumours

Statistics from Altmetric.com

Footnotes

  • Funding PAA is funded by the Row Fogo Charitable Trust and the Scottish Funding Council eDIKT2 project.

  • Competing interests None.

  • Ethics approval Ethics approval was provided by the Lothian Research Ethics Committee.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.