Sporothrix schenckii meningitis in AIDS during immune reconstitution syndrome
- Maria Clara Gutierrez Galhardo,
- Marcus Tulius T Silva,
- Marco Antonio Lima,
- Estevão Portela Nunes,
- Luiz Eduardo C Schettini,
- Rodrigo Fernandes de Freitas,
- Rodrigo de Almeida Paes,
- Elizabeth de Sousa Neves,
- Antonio Carlos Francesconi do Valle
- Evandro Chagas Clinical Research Institute (IPEC), Oswaldo Cruz Foundation (FIOCRUZ), Avenida Brasil, Rio de Janeiro, Brazil
- Correspondence to Dr M T T Silva, Laboratório de Pesquisa Clínica em Neuroinfecção, Instituto de Pesquisa Clínica Evandro Chagas, FIOCRUZ, Avenida Brasil, 4365, Rio de Janeiro, Brazil;
Contributors All authors contributed equally to this report.
- Received 20 January 2009
- Revised 26 March 2009
- Accepted 8 April 2009
- Published Online First 14 April 2010
Sporotrichosis is a fungal disease usually restricted to the cutaneous and lymphatic systems. Visceral involvement is unusual. To date, only 21 cases of sporotrichosis meningitis have been reported, some of these associated with immunosuppression. According to the reported cases, difficulty establishing the correct diagnosis is almost the rule which, undoubtedly, is associated with a worse prognosis. In this report, two HIV infected patients are described who developed meningitis due to Sporothrix schenckii associated with immune reconstitution inflammatory syndrome. This is the first report of sporotrichosis meningitis associated with immune reconstitution inflammatory syndrome in AIDS patients.
Funding MCGG was supported in part by Programa Nacional de DST e AIDS/ MS 46/CV079/2006.
Competing interests None.
Patient consent Obtained.
Ethics approval This study was conducted with the approval of the local ethics committee (FIOCRUZ).
Provenance and peer review Not commissioned; externally peer reviewed.