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Sugar refining reveals a further specificity for autoantibodies in multifocal motor neuropathy
  1. Hugh J Willison
  1. Division of Clinical Neurosciences, Department of Neurology, University of Glasgow, Southern General Hospital, Glasgow, UK
  1. Correspondence to Professor Hugh J Willison, Division of Clinical Neurosciences, Department of Neurology, University of Glasgow, Southern General Hospital, Glasgow G51 4TF, UK; h.j.willison{at}clinmed.gla.ac.uk

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The discovery by Alan Pestronk and colleagues in the mid-1980s of anti-GM1 IgM antibodies as biomarkers for multifocal motor neuropathy (MMN) represented a major milestone in inflammatory neuropathy research.1 After a plethora of complex and occasionally contentious publications over the last 25 years, it is now generally agreed that in the region of 50% of MMN cases harbour such anti-GM1 antibodies. What has remained elusive is the putative antibody specificity for the remaining ‘anti-GM1 negative’ MMN cases. Are there unidentified autoantigens out there, or is their absence indicative of alternative pathological mechanisms that we should be considering? …

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