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Isolated bulbar paralysis in a patient with medullar tau pathology: a case report
  1. J Pretnar-Oblak1,
  2. M Zaletel1,
  3. T M Hajnšek2,
  4. B Meglič1,
  5. I Hočevar-Boltežar3,
  6. M Popović2
  1. 1Department of Neurology, Ljubljana University Medical Centre, Ljubljana, Slovenia
  2. 2Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
  3. 3Department of Otorhinolaryngology and Head & Neck Surgery, Ljubljana University Medical Centre, Ljubljana, Slovenia
  1. Correspondence to Dr Janja Pretnar-Oblak, Ljubljana Medical Centre, Department of Neurology, Zaloska 7, 1000 Ljubljana, Slovenia; janja.pretnar{at}kclj.si

Abstract

Increased morbidity and mortality rates as well as some other manifestations in Alzheimer's disease can be explained by subcortical degeneration. Pathological evidence is scarce but confirmative. We report a 77-year-old patient who presented with a 6-year history of dyspnoea, stridor and dysphagia. Unexpectedly, histopathological examination disclosed extensive degeneration of the medulla by tau pathology. The majority of symptoms and signs could be explained by the medullary tau pathology. Whether the medullary tau pathology in this case was a rare aberrant progression of Alzheimer's disease or a new presentation of tauopathy concomitant with subclinical Alzheimer's disease should be elucidated by additional studies.

  • Alzheimer's disease
  • dysphagia
  • neuropathology
  • respiratory medicine

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Footnotes

  • Competing interests None.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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