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J Neurol Neurosurg Psychiatry 81:907-912 doi:10.1136/jnnp.2009.204123
  • Research paper

Analysis of clinical outcomes according to original treatment groups 16 years after the pivotal IFNB-1b trial

Table 3

Time to the disability endpoints according to duration of IFNB-1b treatment

Duration of time on IFNB-1b treatment
<10% 10–79% ≥80%
Patients reaching EDSS ≥6.0, N (%) 27 (38.6) 76 (46.9) 10 (35.7)
Patients reaching SPMS, N (%) 24 (34.3) 72 (44.4) 8 (28.6)
Patients with EDSS ≥6.0 or SPMS, N (%) 35 (50.0) 94 (58.0) 11 (39.3)
Median time from onset of symptoms to EDSS 6.0 (y)* 12.40 14.95 20.10
Median time from onset of symptoms to SPMS 6.0 (y)* 14.25 16.60 18.80
  • * Only calculated for patients who reached these endpoints.

  • EDSS, Expanded Disability Status Scale; SPMS, secondary progressive multiple sclerosis.

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