Article Text

Wolfram syndrome associated with leukoencephalopathy

Statistics from

A 29-year-old woman born from consanguineous parents developed, since the age of 5, insulin-dependent diabetes mellitus, bilateral optic atrophy, neurosensory hearing loss, ataxia and chronic depression. The patient had normal learning capacities. Clinical examination showed ataxia and reduced lower leg deep tendon reflexes. Testing of cognitive functions revealed clearly a frontal network deficit and amnesic dysfunction together with a mild to moderate depression. Brain MRI …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.