J Neurol Neurosurg Psychiatry 82:97 doi:10.1136/jnnp.2010.205096
  • Neurological picture

Spinal nerve root hypertrophy in chronic ataxic neuropathy with antiglycolipid IgM antibodies

  1. Hugh Willison4
  1. 1Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, Sydney, NSW, Australia
  2. 2Brain and Mind Research Institute, University of Sydney, NSW, Australia
  3. 3Department of Radiology, Royal North Shore Hospital, Sydney, NSW, Australia
  4. 4Division of Clinical Neuroscience, University of Glasgow, Glasgow, UK
  1. Correspondence to Dr M Barnett, Brain and Mind Research Institute, University of Sydney, Lvl 4, 94 Mallett Street, Camperdown NSW 2050, Australia; mbarnett{at}
  • Accepted 16 February 2010
  • Published Online First 11 June 2010

A 61-year-old man presented with a 5 year history of progressive imbalance and clumsiness of the lower limbs, requiring him to look at his feet when walking. He complained of increased sensitivity of the soles of both feet, and occasional paraesthesiae in the toes, but no numbness. There were no upper limb symptoms. Sphincter function was normal. His only other symptom was weight loss of 18 kg over 3 years in the absence of significant gastrointestinal, respiratory or other systemic disease. There was no significant past medical or relevant family history.

On examination, there were no neurocutaneous stigmata. The gait was wide based and Romberg's sign positive. Sensory examination revealed diminished vibration sensation to the medial malleoli, and severe impairment of joint position …

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