Article Text

PDF
Muscle ultrasonography to predict survival in amyotrophic lateral sclerosis
  1. Ilse MP Arts,
  2. Sebastiaan Overeem,
  3. Sigrid Pillen,
  4. Helenius Jurgen Schelhaas,
  5. Machiel J Zwarts
  1. Neuromuscular Centre Nijmegen, Department of Neurology, Donders Institute for Neuroscience, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
  1. Correspondence to Helenius Jurgen Schelhaas, Department of Neurology, Donders Institute for Neuroscience, Radboud University Nijmegen Medical Centre, PO Box 9101, Nijmegen 6500 HB, The Netherlands; HJ.Schelhaas{at}neuro.umcn.nl

Abstract

The authors assessed the prognostic value of muscle ultrasonography in 31 patients with amyotrophic lateral sclerosis (ALS) and compared it with accepted prognostic variables like functional capacity (measured with the Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS)) and muscle strength. Each patient was examined once. The following ultrasonography parameters were determined: muscle thickness, echo intensity (EI) and the presence of fasciculations. Correlations between baseline measurements, preslope values and survival were calculated. EI, disease duration, muscle strength preslope and ALSFRS-R preslope correlated with survival. Using a stepwise multivariate analysis, the combination of EI preslope and ALSFRS-R preslope was shown to have the best predictive value for survival.

  • Ultrasonography
  • survival rate
  • Amyotrophic Lateral Sclerosis
  • prognosis
  • ALS
  • ultrasound

Statistics from Altmetric.com

Footnotes

  • Competing interests None.

  • Ethics approval Ethics approval was provided by The Central Committee on Research Involving Human Subjects.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.