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Amyotrophic lateral sclerosis and vascular risk: a metabolic conundrum
  1. Orla Hardiman
  1. Correspondence to Professor O Hardiman, Department of Neurology, Beaumont Hospital and Trinity College Dublin, Beaumont Road, Dublin 9, Ireland; orla{at}hardiman.net

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Amyotrophic lateral sclerosis (ALS) is a clinically heterogeneous syndrome, characterised by progressive upper and lower motor neuron degeneration, and death from respiratory failure within 2–3 years from diagnosis. Non-motor manifestations of ALS include an associated frontotemporal dementia in 15% and executive dysfunction in a further 20% of cases. ALS shares common features with other neurodegenerative conditions. Alterations in vasculature has been implicated as an early pathogenic mechanism in mouse models of both Alzheimer's disease and ALS.1 Epidemiological studies have shown that cardiovascular risk factors, including elevated blood cholesterol and triglycerides, increase the risk of developing Alzheimer's disease. Whether similar risk factors are associated with ALS is …

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