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Guillain–Barré syndrome (GBS) can be classified into demyelinating and axonal forms based on the underlying pathogenesis. The axonal form of GBS was further classified into two subtypes, acute motor axonal neuropathy (AMAN) and acute motor and sensory axonal neuropathy (AMSAN).1 Capasso et al2 have elegantly demonstrated that sensory fibres are often subclinically involved in AMAN through serial sensory nerve conduction studies (see page 664). They have also shown that reversible conduction failure occurs in sensory as well as motor fibres in AMAN and AMSAN. The authors concluded that both subtypes form a continuous spectrum.
The pathology of AMAN and AMSAN are similar, and both conditions can be preceded by Campylobacter jejuni enteritis.1 …
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