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Interpersonal traits change as a function of disease type and severity in degenerative brain diseases
  1. Marc Sollberger1,2,3,4,
  2. John Neuhaus5,
  3. Robin Ketelle1,2,
  4. Christine M Stanley1,2,
  5. Victoria Beckman1,2,
  6. Matthew Growdon1,2,
  7. Jung Jang1,2,
  8. Bruce L Miller1,2,
  9. Katherine P Rankin1,2
  1. 1Memory and Aging Center, University of California, San Francisco, California, USA
  2. 2Department of Neurology, University of California, San Francisco, California, USA
  3. 3Memory Clinic-Neuropsychology Center, Department of Geriatrics, University Hospital, Basle, Switzerland
  4. 4Department of Neurology, University Hospital, Basle, Switzerland
  5. 5Division of Biostatistics, University of California, San Francisco, California, USA
  1. Correspondence to Dr Katherine P Rankin, Memory and Aging Center, UCSF Department of Neurology, 350 Parnassus Avenue, Suite 905, San Francisco, CA 94143-1207, USA; krankin{at}memory.ucsf.edu

Abstract

Background Different degenerative brain diseases result in distinct personality changes as a result of divergent patterns of brain damage; however, little is known about the natural history of these personality changes throughout the course of each disease.

Objective To investigate how interpersonal traits change as a function of degenerative brain disease type and severity.

Methods Using the Interpersonal Adjective Scales, informant ratings of retrospective premorbid and current scores for dominance, extraversion, warmth and ingenuousness were collected annually for 1 to 4 years on 188 patients (67 behavioural variant frontotemporal dementia (bvFTD), 40 semantic dementia (SemD), 81 Alzheimer's disease (AD)) and 65 older healthy controls. Using random coefficient models, interpersonal behaviour scores at very mild, mild or moderate-to-severe disease stages were compared within and between patient groups.

Results Group-level changes from premorbid personality occurred as a function of disease type and severity, and were apparent even at a very mild disease stage (Clinical Dementia Rating=0.5) for all three diseases. Decreases in interpersonal traits were associated with emotional affiliation (ie, extraversion, warmth and ingenuousness) and more rigid interpersonal behaviour differentiated bvFTD and SemD patients from AD patients.

Conclusions Specific changes in affiliative interpersonal traits differentiate degenerative brain diseases even at a very mild disease stage, and patterns of personality change differ across bvFTD, SemD and AD with advancing disease. This study describes the typical progression of change of interpersonal traits in each disease, improving the ability of clinicians and caregivers to predict and plan for symptom progression.

  • Neurodegenerative diseases
  • dementia
  • personality
  • affiliation
  • mixed effects model
  • behavioural disorder
  • dementia, frontal lobe

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Footnotes

  • Funding This research was supported in part by the National Institute on Ageing (NIA) (5-K23-AG021606-02, PPG P01-AG1972403 and AG19724-01A1); the State of California, Alzheimer's Disease Research Center of California (ARCC) (01-154-20); the Larry L. Hillblom Foundation (2002/2J to KPR); UCSF (GCRC-M01-RR00079); the Swiss National Science Foundation (SNSF) (PBBEB-113383); the Scientific Society Basle; and the Velux Foundation.

  • Competing interests None.

  • Ethics approval Ethics approval was provided by the Institutional Review Board (IRB), University of San Francisco, California, USA.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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