The motor symptoms of Parkinson's disease respond well to dopamine replacement therapies. There are however few treatments available for the non-motor symptoms of the disease, which respond unpredictably to dopaminergic treatments. A variable number of years after treatment has been started for motor symptoms, patients develop fluctuations in their response to dopaminergic therapies. There is therefore much research to try and develop treatments that improve the motor fluctuations seen in Parkinson's disease, and also to treat the non-motor symptoms. Furthermore there are no treatments proven to be effective against the underlying neurodegenerative process and some new avenues of possible treatment for all these aspects will be reviewed in this talk.