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Clinical classification of psychogenic non-epileptic seizures based on video-EEG analysis and automatic clustering
  1. Cécile Hubsch1,
  2. Cédric Baumann2,
  3. Coraline Hingray3,
  4. Nicolaie Gospodaru1,4,
  5. Jean-Pierre Vignal1,5,
  6. Hervé Vespignani1,4,5,
  7. Louis Maillard1,5
  1. 1Central Hospital of Nancy, Department of Neurology, Nancy Cedex, France
  2. 2Department of Epidemiology and Clinical Evaluation, INSERM CIC-EC CIE6, Hospital of Brabois (University Hospital of Nancy), Nancy, France
  3. 3University Hospital of Nancy, CSAPA (Health Care Centre of Accompaniment and Prevention in Addictology), Nancy, France
  4. 4Faculty of Medicine, Nancy-University, Nancy, France
  5. 5CRAN, UMR7039, CNRS, Nancy University, Nancy, France
  1. Correspondence to Louis Maillard, Department of Neurology, Hôpital Central, CHU de Nancy, 29 Avenue du Maréchal de Lattre de Tassigny, 54035 Nancy Cedex, France; l.maillard{at}chu-nancy.fr

Abstract

Background Psychogenic non-epileptic seizures (PNES) or attacks consist of paroxysmal behavioural changes that resemble an epileptic seizure but are not associated with electrophysiological epileptic changes. They are caused by a psychopathological process and are primarily diagnosed on history and video-EEG. Clinical presentation comprises a wide range of symptoms and signs, which are individually neither totally specific nor sensitive, making positive diagnosis of PNES difficult. Consequently, PNES are often misdiagnosed as epilepsy. The aim of this study was to identify homogeneous groups of PNES based on specific combinations of clinical signs with a view to improving timely diagnosis.

Methods The authors first retrospectively analysed 22 clinical signs of 145 PNES recorded by video-EEG in 52 patients and then conducted a multiple correspondence analysis and hierarchical cluster analysis.

Results Five clusters of signs were identified and named according to their main clinical features:

  • dystonic attack with primitive gestural activity (31.6%);

  • pauci-kinetic attack with preserved responsiveness (23.4%);

  • pseudosyncope (16.9%);

  • hyperkinetic prolonged attack with hyperventilation and auras (11.7%);

  • axial dystonic prolonged attack (16.4%).

When several attacks were recorded in the same patient, they were automatically classified in the same subtype in 61.5% of patients.

Conclusion This study proposes an objective clinical classification of PNES based on automatic clustering of clinical signs observed on video-EEG. It also suggests that PNES are stereotyped in the same patient. Application of these findings could help provide an objective diagnosis of patients with PNES.

  • Psychogenic non-epileptic seizure
  • video-EEG
  • diagnosis
  • classification
  • clinical neurology
  • EEG
  • epilepsy
  • neuropsychiatry
  • paroxysmal disorder

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Footnotes

  • See Editorial Commentary, p 946

  • Linked article 246751.

  • Competing interests None.

  • Patient consent Obtained.

  • Ethics approval Ethics approval was provided by the local ethic committee, in Nancy, France.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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