Movement related potentials and oscillatory activities in the human internal globus pallidus during voluntary movements
- Eric W Tsang1,2,
- Clement Hamani3,
- Elena Moro4,
- Filomena Mazzella1,
- Andres M Lozano2,3,
- Mojgan Hodaie2,3,
- I-Jin Yeh1,4,5,
- Robert Chen1,2,4
- 1Division of Brain Imaging and Behaviour Systems-Neuroscience, Toronto Western Research Institute, University Health Network, Toronto, Canada
- 2Institute of Medical Science, University of Toronto, Toronto, Canada
- 3Department of Surgery, Division of Neurosurgery, University of Toronto, Toronto, Canada
- 4Department of Medicine, Division of Neurology, University of Toronto, Toronto, Canada
- 5Department of Neurology, Songde Branch, Taipei City Hospital, Taipei, Taiwan
- Correspondence to Dr R Chen, Toronto Western Hospital, McLaughlin Pavilion, 7th Floor Room 411, 399 Bathurst Street, Toronto, Ontario M5T 2S8, Canada;
- Received 2 February 2011
- Revised 11 May 2011
- Accepted 25 May 2011
- Published Online First 23 June 2011
Objective To study internal globus pallidus (GPi) activities and the interactions among the bilateral GPi and motor cortical areas during voluntary movements.
Methods Five patients with cervical dystonia who underwent bilateral GPi deep brain stimulation (DBS) were studied. Local field potentials from the GPi DBS electrodes and EEG were recorded while the patients performed externally triggered and self-initiated right wrist movements.
Results Movement related potentials were recorded at the GPi bilaterally before the onset of self-initiated but not externally triggered movements. In all movements studied, frequency analysis revealed a ∼10–24 Hz beta event related desynchronisation at bilateral GPi and with EEG recorded over the mid-frontal (Cz-Fz) and the bilateral sensorimotor cortical regions (C3/C4-Cz). A ∼64–68 Hz, gamma event related synchronisation was found with EEG recorded over the mid-frontal (Cz-Fz), the sensorimotor cortices (C3-Cz) and the GPi contralateral to movements. Both beta event related desynchronisation and gamma event related synchronisation occurred before the onset of self-initiated movements and at the onset of externally triggered movements. There was a resting ∼5–18 Hz coherence between the bilateral GPi, which attenuated for ∼1 s during movements. Gamma coherences were observed between EEG recorded over the mid-frontal (Cz-Fz), contralateral sensorimotor cortices (C3-Cz) and the GPi from 0 to 0.5 s after movement onset for externally triggered movements and from 0.5 s before to 0.5 s after movement onset for self-initiated movements.
Conclusions The beta and gamma frequency bands in the GPi are modulated by the preparation of self-initiated movements and the execution of self-initiated and externally triggered movements. The 5–18 Hz coherence at the bilateral GPi may be related to dystonia and its attenuation may facilitate voluntary movements.
Funding This work was supported by the Canadian Institutes of Health Research (grant No CIHR, MOP15128 to RC). EWT was supported by a CIHR Canada Graduate Scholarship Doctoral Award. AML is supported by the Canada Research Chair in Neurosciences and RC is supported by a CIHR-Industry (Medtronic Inc.) Partnered Investigator Award and the Catherine Manson Chair in Movement Disorders.
Competing interests CH received honoraria from and is a consultant of St Jude Medical. EM received honoraria for serving on the educational advisory board for Medtronic, was a consultant for Medtronic Canada and received honoraria for lecturing from Medtronic. AML received honoraria and research grants from Medtronic Inc and St Jude Medical. MH has received research grant support from Medtronic Inc. RC received consulting fees from Medtronic Inc.
Ethics approval This study was conducted with the approval of the University Health Network Research Ethics Board.
Provenance and peer review Not commissioned; externally peer reviewed.