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J Neurol Neurosurg Psychiatry 83:1031-1032 doi:10.1136/jnnp-2012-303032
  • PostScript
  • Letter

Psychosis, C9ORF72 and dementia with Lewy bodies

  1. Stuart Pickering-Brown2,3
  1. 1Cerebral Function Unit, Greater Manchester Neuroscience Centre, Salford Royal Foundation Trust, Salford, UK
  2. 2The University of Manchester, Manchester Academic Health Science Centre (MAHSC), Manchester, UK
  3. 3Mental Health and Neurodegeneration Research Group, AV Hill Building, University of Manchester, Manchester, UK
  1. Correspondence to Professor Julie S Snowden, Cerebral Function Unit, Greater Manchester Neuroscience Centre, Salford Royal Foundation Trust, Salford M6 8HD, UK; julie.snowden{at}manchester.ac.uk
  1. Contributors JS prepared the manuscript, contributed to clinical data acquisition and patient identification and interpretation of findings, SR carried out genetic data acquisition, CL documented hallucinations and delusions from patient records, JH contributed to data recording and matched clinical and genetic data to identify patients who met criteria for the study, JT contributed to data acquisition and commented on the manuscript, AR contributed to data acquisition and commented on the manuscript, MJ contributed to data acquisition and commented on the manuscript, AG contributed to data acquisition and commented on the manuscript, DN contributed to data acquisition and commented on the manuscript, DM prepared the genetic database and contributed to data interpretation and commented on the manuscript, SPB organised genetic analysis, interpreted genetic data and commented on the manuscript.

  • Received 19 April 2012
  • Revised 22 May 2012
  • Accepted 3 July 2012
  • Published Online First 25 July 2012

Introduction

Hexanucleotide repeat expansions in the C9ORF72 gene are an important cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis.1 ,2 Whether they have a role in other conditions remains unclear.3 ,4 We previously identified in FTD a strong association between repeat expansions in C9ORF72 and the presence of psychosis.4 This raises the question whether C9ORF72 expansions might also have a role in dementia with Lewy bodies (DLB), in which hallucinations and delusions are prevalent. The study addressed this question.

Methods

The cohort comprised 102 consecutive patients who fulfilled criteria for ‘probable DLB’, exhibiting at least two of the cardinal features: fluctuating …

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