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Prediction of the rate of progression for an individual with multiple sclerosis (MS) is a difficult task due to the significant intrapersonal and interpersonal variability in the rate of change of disability. The most commonly used measure of disability is the expanded disability status score (EDSS),1 which has been modified to take into account disease duration to produce the global multiple sclerosis severity score (MSSS), which has provided clinicians and researchers with a tool to quantify the degree of neurological disability for a given duration of MS.2 However, the MSSS has not been validated as a longitudinal measure. The authors concluded that the MSSS could be …
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