Classification and stratification of primary progressive aphasia: CSF biomarkers as a useful tool?
- Eloi Magnin1,2
- 1Department of Neurology, Memory center (CMRR), CHU Besançon, France
- 2Clinical Investigation Center CIC-IT 808 INSERM, CHU Besançon, France
- Correspondence to Dr Eloi Magnin, Department of Neurology, CMRR, CHU Besançon, 25000 Besançon, France;
- Received 5 March 2012
- Accepted 20 March 2012
In the paper by Kas et al,1 the authors report a distinct brain perfusion pattern associated with a CSF biomarker profile in a retrospective study on a large cohort of 34 primary progressive aphasia (PPA) patients (see page 695). Their logopenic variant group is, to our knowledge, the largest series of logopenic PPA patients currently described in the literature. PPA subjects with a CSF profile of Alzheimer's disease have left temporoparietal hypoperfusion such as in logopenic variants of PPA, while those with …