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Immune-mediated neuropathies induced by immunosuppressive treatment
  1. Satoshi Kuwabara,
  2. Sonoko Misawa
  1. Department of Neurology, Graduate School of Medicine, Chiba University
  1. Correspondence to Dr Satoshi Kuwabara, Department of Neurology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan; kuwabara-s{at}faculty.chiba-u.jp

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Chronic inflammatory demyelinating polyneuropathy (CIDP) is an immune-mediated neuropathy and the efficacy of immunosuppressive or immunomodulating treatments with corticosteroids, intravenous immunoglobulin and plasma exchange has been established.1 2 For patients refractory to these conventional therapies, other immunosuppressants such as cyclophosphamide, ciclosporin rituximab and tumour necrosis factor (TNF)-α antagonists have been trialed.3 4

Conversely, several studies have established that immunosuppressive agents may trigger the development of CIDP. Recent examples include CIDP induced by TNF-α antagonists such as infliximab and etanercept.5 Separately, therapy with the TNF-α antagonists for rheumatoid …

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