rss

This article has a correction

Please see: J Neurol Neurosurg Psychiatry 2012;83:1132

J Neurol Neurosurg Psychiatry 83:725-729 doi:10.1136/jnnp-2012-302436
  • Movement disorders
  • Research paper

Associated movement disorders in orthostatic tremor

  1. Susan Fox1
  1. 1Division of Neurology, Movement Disorders Centre, Edmond J Safra Program in Parkinson's disease, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
  2. 2Department of Neurosciences, Hospital de Santa Maria, Lisbon, Portugal
  3. 3Neurological Clinical Research Unit, Instituto de Medicina Molecular, Faculty of Medicine of Lisbon, Lisbon, Portugal
  4. 4Neuromuscular Unit, Instituto de Medicina Molecular, Faculty of Medicine of Lisbon, Lisbon, Portugal
  1. Correspondence to Dr T A Mestre, Division of Neurology, Movement Disorders Centre, Edmond J Safra Program in Parkinson's Disease, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada; tmestre{at}uhnresearch.ca
  1. Contributors TAM: research project—conception, organisation and execution; statistical analysis—design and execution; writing of the first draft of the manuscript; and video editing. AEL: research project—documentation of clinical data; and manuscript preparation—review and critique. JJF: research project—documentation of clinical data; and manuscript preparation—review and critique. VA: research project—documentation of clinical data and documentation of neurophysiological data; and manuscript preparation—review and critique. MDC: Manuscript preparation—documentation of neurophysiological data, and review and critique. JM: research project—documentation of clinical data; and manuscript preparation—review and critique. RC: documentation of neurophysiological data; and manuscript preparation—review and critique. SHF: research project—conception and organisation; statistical analysis—review and critique; and manuscript preparation—review and critique.

  • Received 3 February 2012
  • Revised 4 April 2012
  • Accepted 5 April 2012
  • Published Online First 10 May 2012

Abstract

Introduction Orthostatic tremor is a rare tremor syndrome triggered exclusively by standing, with pathognomonic neurophysiological features. More recently, it has been suggested that orthostatic tremor can present either in isolation (pure orthostatic tremor) or associated with other movement disorders (orthostatic tremor-plus). The present study aims at expanding the knowledge concerning orthostatic tremor associated with other movement disorders.

Methods A retrospective case review of the clinical and neurophysiological data of patients diagnosed with orthostatic tremor.

Results Median age of onset was 61 years with a median diagnostic delay of 4.5 years. Orthostatic tremor-plus accounted for eight cases (30.8%). The associated movement disorders were Parkinson's disease (n=1), parkinsonism (n=1), progressive supranuclear palsy (n=1), restless leg syndrome (n=1), multifocal action tremor (n=2), pathological proven dementia with Lewy bodies (n=1) and focal dystonia of the arm (n=1). There were no significant differences between primary orthostatic tremor and orthostatic tremor-plus in demographics, clinical presentation of orthostatic tremor, findings in neurophysiological studies and response to treatment. In the majority of cases (n=18, 72%), there was a progressive and disabling course with refractoriness to medical therapy without significant differences between pure orthostatic tremor and orthostatic tremor-plus.

Conclusion One of the largest series on orthostatic tremor is presented and the second only focused on additional movement disorders. A progressive course was found, with increasing disability associated with orthostatic tremor. Dementia with Lewy bodies and task specific arm dystonia are reported for the first time as associated movement disorders.

Footnotes

  • Funding TAM was partially supported through an Edmond J Safra Movement Disorders fellowship.

  • Competing interests None.

  • Patient consent Obtained.

  • Ethics approval The local ethics committee approved the study.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Podcasts
Visit the full archive of podcasts for JNNP here >>

Free sample
This recent issue is free to all users to allow everyone the opportunity to see the full scope and typical content of JNNP.
View free sample issue >>

Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.

Navigate This Article