Mortality in a cohort of patients with psychogenic non-epileptic seizures
- Correspondence to Dr Roderick Duncan, Department of Neurology, West of Scotland Regional Epilepsy Service, Southern General Hospital, Govan Road, Glasgow G51 4TF, UK;
Contributors RD contributed to the study design, analysis and writing of the manuscript. MO contributed to the design and data collection for the original study. JW-L assisted in data collection and analysis.
- Received 2 April 2012
- Revised 30 April 2012
- Accepted 6 May 2012
Some evidence suggests that psychogenic non-epileptic seizures (PNES) are associated with increased mortality. The authors obtained death certificate information in a cohort of 260 patients who presented with PNES between 1999 and 2004. The follow-up period averaged 7.92 years, during which 17 patients died, 12/17 were under the age of 75 years, giving a premature (<75 years) mortality rate of 0.58%, compared with a Scottish mortality rate for the 40–75 years age group of 0.41% per year. The main predictor of death was the patient age at presentation of PNES. There was no correlation with withdrawal of anticonvulsant medication, and death certificate information provided no evidence to suggest that the deaths were related to the seizure disorder. The population had a high mean deprivation rank, providing a possible explanation for a modest increase in premature death rate.
- Psychogenic non-epileptic seizures
- somatisation disorder
- head injury
Competing interests None.
Ethics approval The ethics approval was provided by Southern General Hospital Research Ethics Committee.
Provenance and peer review Not commissioned; externally peer reviewed.