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Research paper
Lipid profiles are associated with lesion formation over 24 months in interferon-β treated patients following the first demyelinating event
  1. Bianca Weinstock-Guttman1,
  2. Robert Zivadinov1,2,
  3. Dana Horakova3,
  4. Eva Havrdova3,
  5. Jun Qu4,
  6. Grace Shyh4,
  7. Elizabeth Lakota4,
  8. Kerri O'Connor4,
  9. Darlene Badgett4,
  10. Miriam Tamaño-Blanco4,
  11. Michaela Tyblova3,
  12. Sara Hussein2,
  13. Niels Bergsland2,
  14. Laura Willis2,
  15. Jan Krasensky5,
  16. Manuela Vaneckova5,
  17. Zdenek Seidl5,
  18. Murali Ramanathan1,4
  1. 1Department of Neurology, State University of New York, Buffalo, New York, USA
  2. 2Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York, Buffalo, New York, USA
  3. 3Department of Neurology, Center of Clinical Neuroscience, Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Charles University, Prague, Czech Republic
  4. 4Department of Pharmaceutical Sciences, State University of New York, Buffalo, New York, USA.
  5. 5Department of Radiology, 1st Faculty of Medicine and General University Hospital, Charles University, Prague, Czech Republic
  1. Correspondence to Professor Murali Ramanathan, Department of Pharmaceutical Sciences, State University of New York, Buffalo, 355 Kapoor Hall, Buffalo, NY 14214-8033, USA; Murali{at}Buffalo.Edu

Abstract

Objectives To investigate the associations of serum lipid profile with disease progression in high-risk clinically isolated syndromes (CIS) after the first demyelinating event.

Methods High density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) were obtained in pretreatment serum from 135 high risk patients with CIS (≥2 brain MRI lesions and ≥2 oligoclonal bands) enrolled in the Observational Study of Early Interferon β-1a Treatment in High Risk Subjects after CIS study (SET study), which prospectively evaluated the effect of intramuscular interferon β-1a treatment following the first demyelinating event. Thyroid stimulating hormone, free thyroxine, 25-hydroxy vitamin D3, active smoking status and body mass index were also obtained. Clinical and MRI assessments were obtained within 4 months of the initial demyelinating event and at 6, 12 and 24 months.

Results The time to first relapse and number of relapses were not associated with any of the lipid profile variables. Higher LDL-C (p=0.006) and TC (p=0.001) levels were associated with increased cumulative number of new T2 lesions over 2 years. Higher free thyroxine levels were associated with lower cumulative number of contrast-enhancing lesions (p=0.008). Higher TC was associated as a trend with lower baseline whole brain volume (p=0.020). Higher high density lipoprotein was associated with higher deseasonalised 1,25-dihydroxy vitamin D3 (p=0.003) levels and a trend was found for deseasonalised 25-hydroxy vitamin D3 (p=0.014).

Conclusions In early multiple sclerosis, lipid profile variables particularly LDL-C and TC levels are associated with inflammatory MRI activity measures.

  • Multiple Sclerosis
  • Mri
  • Clinical Neurology
  • Neurobiology
  • Neuroradiology

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