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DOES JCV ANTIBODY POSITIVITY ENCOURAGE CESSATION OF NATALIZUMAB THERAPY IN MULTIPLE SCLEROSIS?
  1. Roisin Lonergan,
  2. Katie Kinsella,
  3. Siobhan Kelly,
  4. Marguerite Duggan,
  5. Jacqueline Scott,
  6. Killian O'Rourke,
  7. Timothy Lynch,
  8. Michael Hutchinson,
  9. Niall Tubridy,
  10. Christopher McGuigan
  1. St. Vincent's University Hospital; Mater Misericordiae Hospital

    Abstract

    Background Natalizumab, a monoclonal α–4–integren receptor antibody, is an effective immunomodulator in highly active relapsing remitting Multiple Sclerosis (HARRMS). Natalizumab has been associated with PML (progressive multifocal leucoencephaopathy), due to opportunistic reactivation of JC polyomavirus (JCv). PML risk may influence decisions to continue therapy. Risk relates to 3 identified risk factors: serum anti–JCv antibodies, prior immunosuppression and prolonged natalizumab therapy (>2 years). Recent commercial availability of a serum JCv–antibody screening test (STRATIFY JCV TM) has been incorporated into a risk–stratification algorithm, presented to patients to help guide treatment.

    Influence of antibody testing on risk perception and decision to proceed with treatment has not been widely established.

    Aim To examine treatment decisions of patients receiving natalizumab based on their JCv–antibody status.

    Patients and methods Serum JCv–antibodies tested annually in patients receiving natalizumab for HARRMS. Clinical data and decisions to stop natalizumab based on JCv status recorded.

    Results JCv antibody status was available in 112 natalizumab patients. Mean natalizumab duration 27.4 months (2–72). Antibodies detected in 55 (49.1%): 2 (3.6%) stopped due to JCv+ve alone, 14 (25.5%) due to prolonged therapy (>2years), 1 (1.8%) due to prolonged therapy and past immuosuppression, 3 (5.5%) disability progression, 1 (1.8%) to conceive. (12.3% of JCv negative patients stopped due to prolonged therapy).

    No significant difference in mean natalizumab duration or disease–modifying therapy history between JCv Ab+ve and Ab–ve groups (p>0.05). Other PML risks (>2 years, past immunosuppression) did not differ significantly between JCv+ve patients who opted to continue compared to those choosing to stop (p>0.05).

    Discussion JCv antibody status had little influence on this cohort's decision to discontinue or remain on natalizumab therapy. It is important that patients understand therapeutic benefits and potential risks of alternative treatments before discontinuing due to JCv status alone. Further validation of this risk stratification measure is important.

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