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One of the major factors influencing the quality of healthcare is the responsiveness of clinicians to new evidence and their willingness to implement findings into routine clinical practice in a timely way.1 The factors that affect the efficiency of getting evidence into practice are complex; a good example of this is illustrated in the paper by Ankolekar et al.2 The Clots in Legs or sTockings after Stroke (CLOTS) 1 trial definitively showed that compression stockings after stroke did not prevent venous thromboembolism. The trial was well conducted and adequately powered for the primary outcome, so there was little room for debate about the validity of the result. Running concurrently with the CLOTS 1 trial and continuing beyond it …
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