J Neurol Neurosurg Psychiatry 84:585-586 doi:10.1136/jnnp-2012-302487
  • Migraine
  • Review

Aspirin for acute migraine headaches in adults

  1. Henry McQuay2
  1. 1Royal College of Physicians, London, UK
  2. 2Pain Research, Nuffield Department of Clinical Neurosciences (Nuffield Division of Anaesthetics), University of Oxford, Oxford, UK
  1. Correspondence to Dr Varo Kirthi, Clinical Fellow to the President, Royal College of Physicians, 11 St Andrew Place Regent's Park, London NW1 4LE, UK; varo.kirthi{at}
  1. Contributors VK authored the manuscript which was reviewed by SD and RAM. HJM is Head of the Pain Research Unit. For the original Cochrane review, all authors were involved with planning and writing the protocol, while VK and SD carried out the searches, identified studies for inclusion, extracted data and performed analyses. RAM helped with analyses, HJM acted as arbitrator, and all review authors were involved in the writing.

  • Received 13 February 2012
  • Revised 15 May 2012
  • Accepted 10 June 2012
  • Published Online First 24 July 2012

Clinical bottom line

A single oral dose of aspirin 900 mg or 1000 mg is more effective than placebo at resolving migrainous headache pain at 2 h and providing relief that is sustained over 24 h.1 Co-administration of metoclopramide 10 mg may provide additional pain relief and a greater reduction in associated symptoms, especially nausea.1


Migraine is a common, disabling, headache disorder, with considerable social and economic impact on the individual and society. Despite experiencing a high level of disability, most migraine sufferers do not seek professional …

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