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J Neurol Neurosurg Psychiatry 84:591 doi:10.1136/jnnp-2012-304230
  • Editorial commentary

Daily or alternative, that is the question: steroid therapy for Duchenne muscular dystrophy patients

  1. Ichizo Nishino2,3
  1. 1Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
  2. 2Department of Neuromuscular Research, National Institute of Neuroscience, Tokyo, Japan
  3. 3Department of Clinical Development, Translational Medical Center, National Center of Neurology and Psychiatry, Tokyo, Japan
  1. Correspondence to Dr Ichizo Nishino, Department of Neuromuscular Research, National Institute of Neuroscience, and Department of Clinical Development, Translational Medical Center, National Center of Neurology and Psychiatry, Tokyo, Japan; nishino{at}ncnp.go.jp
  • Received 5 November 2012
  • Revised 9 November 2012
  • Accepted 12 November 2012
  • Published Online First 25 January 2013

Daily steroid use brings longer ambulation time but also more adverse effects, except for orthopaedic complications

Duchenne muscular dystrophy (DMD) is an X-linked muscular dystrophy known to affect one in 3600 live male births and leads to progressive proximal muscle weakness in the first years, and orthopaedic, respiratory and cardiac complications in the teens. Typically the patients would lose the ability of ambulation at around the age of 10 years and decease in young adulthood if untreated. In recent years, corticosteroid treatment has been proved to prolong ambulation, improve quality of life and survival. Moreover, it has also shown efficacy in reducing the degree of scoliosis and improving cardiopulmonary function. …

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