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Monitoring intravenous immunoglobulin dosing regimens in chronic inflammatory demyelinating polyneuropathy: search for a biomarker
  1. Benjamin R Wakerley,
  2. Nobuhiro Yuki
  1. Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
  1. Correspondence to Professor Nobuhiro Yuki, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Unit 09-01, Centre for Translational Medicine, 14 Medical Drive, Singapore 117599, Singapore; mdcyuki{at}nus.edu.sg

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The clinical effectiveness and relative ease of administering intravenous immunoglobulin (IVIG) make it the preferred treatment option for several immune mediated conditions including chronic inflammatory demyelinating polyneuropathy (CIDP). Timing and dosage of IVIG vary considerably in CIDP between patients. The cost implications for establishing sensitive and reliable biomarkers, which accurately predict IVIG dosing regimens and avoid overtreatment are therefore considerable and warrant investigation. In this issue, Kuitwaard and colleagues examine the variability of serum IgG levels in patients receiving IVIG for treatment of CIDP.1 They demonstrate …

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