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PD REHAB RCT OF PHYSIOTHERAPY AND OT IN PARKINSON'S DISEASE
  1. Carl Clarke1,2,
  2. Smitaa Patel1,
  3. Rebecca Woolley1,
  4. Natalie Ives1,
  5. Caroline Rick1,
  6. Keith Wheatley1,
  7. Marion Walker1,
  8. Catherine Sackley1
  1. 1University of Birmingham
  2. 2Sandwell and West Birmingham Hospitals NHS Trust
  3. 3University of Nottingham
  4. 4University of East Anglia

Abstract

38 centres randomised PD outpatients with limitations in activities of daily living to PT+OT or no therapy. Primary outcome – instrumental ADL (Nottingham-Extended-ADL-scale; NEADL). Secondary outcomes–health-related quality of life (Parkinson's-Disease-Questionnaire-39, EuroQoL-EQ-5D), adverse events, carer QoL (Short-Form-12). Assessments at 0, 3, 9, and 15-months.

762 patients with mild to moderate PD were randomised. Mean therapist contact time–4 visits; 55 minutes; over 8-weeks. At 3-months, there was no difference in NEADL total score between groups (difference 0.5 points, p=0.4) or PDQ-39 summary index (difference 0.007 points, p=1.0). EQ-5D quotient was of borderline significance in favour of therapy (difference −0.03, p=0.04). There was no difference in carer SF-12 physical component score (difference −0.6 points, p=0.5), but less decline in carer SF-12 mental component score with PT+OT (difference −2.1, p=0.02). There were no trends towards a therapy effect with age, NEADL or disease severity.

NHS PT+OT produced no benefits on ADL or QoL in mild to moderate PD.

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