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Obstructive sleep apnoea, restless leg syndrome and Charcot-Marie-Tooth disease type 1: important associations
  1. Mary M Reilly
  1. Correspondence to Professor Mary M Reilly, MRC Centre for Neuromuscular Diseases, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK; m.reilly{at}ucl.ac.uk

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In the paper by Boentert et al1 the authors report an increased incidence of obstructive sleep apnoea (OSA), restless leg syndrome (RLS) and periodic limb movements in sleep (PLMS) in a study of 61 patients with Charcot-Marie-Tooth disease type 1 (CMT1) (mostly CMT1A) compared to a control group of insomnic patients. OSA was reported in almost 38% of patients (5% controls) with a male preponderance and RLS in 41% (16% controls) with a female preponderance. Although PLMS was common (41% of CMT1 patients), it did not reduce sleep quality. The severity of OSA is measured by the apnoea–hypopnoea index (AHI), the …

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