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  • M16 D1R and A2AR Blockade Normalises PKA Activity and Improves Hippocampal-dependent Cognitive Dysfunction but not Motor Deficits in Huntington’s Disease

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Experimental therapeutics – preclinical
M16 D1R and A2AR Blockade Normalises PKA Activity and Improves Hippocampal-dependent Cognitive Dysfunction but not Motor Deficits in Huntington’s Disease

Authors

  • A Saavedra 1Departament de Biologia Cellular, Immunologia i Neurociències, Facultat de Medicina, Universitat de Barcelona, 08036 Barcelona, Spain2Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain3Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Spain PubMed articlesGoogle scholar articles
  • S Tyebji 1Departament de Biologia Cellular, Immunologia i Neurociències, Facultat de Medicina, Universitat de Barcelona, 08036 Barcelona, Spain2Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain3Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Spain PubMed articlesGoogle scholar articles
  • PM Canas 4CNC-Center for Neurosciences and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal5Faculty of Medicine, University of Coimbra, 3004-517 Coimbra, Portugal PubMed articlesGoogle scholar articles
  • A Pliassova 4CNC-Center for Neurosciences and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal5Faculty of Medicine, University of Coimbra, 3004-517 Coimbra, Portugal PubMed articlesGoogle scholar articles
  • JM Delgado-García 6División de Neurociencias, Universidad Pablo de Olavide, 41013 Sevilla, Spain PubMed articlesGoogle scholar articles
  • J Alberch 1Departament de Biologia Cellular, Immunologia i Neurociències, Facultat de Medicina, Universitat de Barcelona, 08036 Barcelona, Spain2Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain3Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Spain PubMed articlesGoogle scholar articles
  • RA Cunha 4CNC-Center for Neurosciences and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal5Faculty of Medicine, University of Coimbra, 3004-517 Coimbra, Portugal PubMed articlesGoogle scholar articles
  • A Gruart 6División de Neurociencias, Universidad Pablo de Olavide, 41013 Sevilla, Spain PubMed articlesGoogle scholar articles
  • E Pérez-Navarro 1Departament de Biologia Cellular, Immunologia i Neurociències, Facultat de Medicina, Universitat de Barcelona, 08036 Barcelona, Spain2Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain3Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Spain PubMed articlesGoogle scholar articles

Citation

Saavedra A, Tyebji S, Canas P, et al
M16 D1R and A2AR Blockade Normalises PKA Activity and Improves Hippocampal-dependent Cognitive Dysfunction but not Motor Deficits in Huntington’s Disease
Journal of Neurology, Neurosurgery & Psychiatry 2014;85:A99-A100.

Publication history

  • First published September 17, 2014.
Online issue publication 
April 13, 2016

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