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ALEMTUZUMAB IMPROVES 3-YEAR QUALITY OF LIFE IN CARE-MS II
  1. Alasdair Coles1,
  2. Gavin Giovannoni2,
  3. Thibault Moreau3,
  4. Eva Havrdova4,
  5. David Margolin5,
  6. Linda Kasten6,
  7. Barry Singer7
  1. 1University of Cambridge School of Clinical Medicine, Cambridge, UK
  2. 2Queen Mary University of London, Barts and The London School of Medicine
  3. 3Burgundy University, Dijon University Hospital, Dijon, France
  4. 4First Medical Faculty, Charles University in Prague, Prague, Czech Republic
  5. 5Genzyme, a Sanofi company, Cambridge, MA, USA
  6. 6PROMETRIKA, LLC, Cambridge, MA, USA
  7. 7MS Center for Innovations in Care, St. Louis, MO, USA

Abstract

In the 2-year, phase 3 CARE–MS II study (NCT00548405) of relapsing-remitting multiple sclerosis (RRMS) patients with inadequate efficacy response to prior therapy, alemtuzumab demonstrated superior efficacy and quality-of-life (QoL) improvements versus subcutaneous interferon beta-1a, with manageable safety. Here, QoL outcomes are examined in alemtuzumab-treated patients at Year 3 in an ongoing extension study (NCT00930553). 393 of 435 alemtuzumab 12 mg-treated patients entered the extension study; 80 received as-needed alemtuzumab retreatment during Year 3. Mean Functional Assessment of multiple sclerosis total score (scale 0–176) improved from baseline to year 3 (119.1 vs 124.8; P<0.0001), with 5 of 6 subscales significantly improved. Mean Short-Form 36–Item survey physical and mental component summary scores (scale 1–100) rose from baseline to Year 3 (42.7 vs 44.7; P<0.0001, and 44.9 vs 46.5; P=0.042, respectively), with 6 of 8 subscales improved, and 82% and 73% of patients, respectively, having a stable or improved score at Year 3. EuroQol 5–dimensional visual analogue scale score improved from baseline to Year 3 (70.1 vs 73.0; P=0.0045). Overall sustained improvement in physical, mental, and emotional aspects of QoL were observed through 3 years in this population of alemtuzumab-treated RRMS patients, even though most patients received only 2 alemtuzumab treatment courses.

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