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Rethinking of doxycycline therapy in Creutzfeldt-Jakob disease
  1. Maurizio Pocchiari,
  2. Anna Ladogana
  1. Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Rome, Italy
  1. Correspondence to Professor Maurizio Pocchiari, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Rome 161, Italy; maurizio.pocchiari{at}iss.it

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Compassionate use of doxycycline, a tetracycline antibiotic, in patients with Creutzfeldt-Jakob disease (CJD) revealed an increased survival of 4–7 months as compared with historical controls, a result not confirmed by a randomised, double blind, placebo-controlled trial.1 Is then therapy with doxycycline for patients with CJD over? The report of Assar et al2 on a single patient with variably protease-sensitive prionopathy (VPSPr),3 a rare subtype form of sporadic CJD, who received 4-year treatment with doxycycline at a relatively early stage of disease, suggests it is not and encourages novel studies on the use of doxycycline in prion diseases. The patient, who carried the commonly VPSPr-associated valine homozygosity …

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    Hamid Assar Raffi Topakian Serge Weis Jasmin Rahimi Johannes Trenkler Romana Höftberger Fahmy Aboulenein-Djamshidian Thomas Ströbel Herbert Budka Helen Yull Mark W Head James W Ironside Gabor G Kovacs