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Neurolymphomatosis as the primary presentation of non-Hodgkin's Lymphoma
  1. Hsin-Hsi Tsai1,
  2. Ya-Fang Chen2,
  3. Sung-Tsang Hsieh1,3,4,5,
  4. Chi-Chao Chao1
  1. 1Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan
  2. 2Department of Radiology, National Taiwan University Hospital, Taipei, Taiwan
  3. 3Department of Anatomy and Cell Biology, National Taiwan University College of Medicine, Taipei, Taiwan
  4. 4Graduate Institute of Brain and Mind Sciences, National Taiwan University College of Medicine, Taipei, Taiwan
  5. 5Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan
  1. Correspondence to Dr Chi-Chao Chao, Department of Neurology, National Taiwan University Hospital, 7 Chung-Shan S. Road, Taipei 10002, Taiwan; ccchao{at}ntu.edu.tw

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A 57-year-old previous healthy woman was referred to our hospital due to progressive weakness, numbness and pain in the left leg for 3 months. She initially suffered from pain and numbness at left buttock and posteriolateral thigh without limitation in her daily activities. Two months later, the pain rapidly progressed to her left calf and dorsal foot, and weakness in left ankle followed by left proximal leg developed. She also felt numbness at right index finger, clumsiness in right hand and stress urinary incontinence. Neurological examinations showed normal functions of cranial nerves, weakness in flexion and extension of left hip, knee and ankle. Deep tendon reflexes at left knee and ankle were absent. Sensory evaluation showed hypoesthesia at left posteriolateral thigh and leg, and dorsal foot. Nerve conduction studies and electromyography showed (1) reduced amplitudes of compound muscle action potentials …

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