Article Text

PDF
107
NEUROMELANIN-SENSITIVE RESONANCE IMAGING AS A PARKINSON'S DISEASE BIOMARKER
  1. Antonio Martin-Bastida1,
  2. Stefan Schwarz2,
  3. Yue Xing2,
  4. Sara Pietracupa1,
  5. David Burn3,
  6. Monty Silverdale4,
  7. Nin Bajaj5,
  8. Donald Grosset6,
  9. Dorothee Auer2,
  10. Piccini Paola1
  1. 1 Imperial College London
  2. 2 University of Nottingham
  3. 3 Newcastle University
  4. 4 Salford Royal NHS Foundation Trust, Greater Manchester
  5. 5 Nottingham University Hospitals
  6. 6 Queen Elizabeth University Hospital, Glasgow

Abstract

Introduction Neuromelanin-sensitive (NM) magnetic resonance imaging visualizes dopaminergic neuronal loss in the substantia nigra pars compacta (SNc) in Parkinson's disease (PD), and may be a useful diagnostic marker

Methods Fifty-five patients with early stage PD and 12 age-matched healthy volunteers (HV) underwent 3T MR scanning. SNc volumes were determined according to the threshold of background signal intensity+3SD. SNc volumes were also compared between HV and three PD sub-groups as divided by UPDRS 3 scores with tertile calculations, using analysis of covariance (ANCOVA), adjusting by regional volumes and age.

Results PD patients showed marked reductions of SNc volumes compared to HV (p<0.001). Within the PD group, nigral volume reductions were consistent for clinical laterality (p<0.05). Nigral volumes inversely correlated with UPDRS 3 (p<0.01), and were lowest in PD patients in the worst tertile for motor severity, compared to the more mildly affected PD cases (p<0.05) and HV groups (p<0.001).

Discussion Our results confirm that NM-sensitive MR imaging helps distinguish early PD from healthy volunteers. In addition, the significant relationship between nigral volume and motor severity suggests that the method could be developed as a disease biomarker.

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.