Article Text

PDF
125
ALEMTUZUMAB PERSISTENTLY SLOWS BRAIN VOLUME LOSS IN RRMS
  1. Alasdair Coles1,
  2. Douglas Arnold2,3,
  3. Frederik Barkhof4,
  4. Massimo Filippi5,
  5. Hans-Peter Hartung6,
  6. Eva Havrdova7,
  7. Krzysztof Selmaj8,
  8. David Margolin9,
  9. Karthinathan Thangavelu9,
  10. Sven Schippling10,
  11. on behalf of the CARE-MS I and CARE-MS II Investigators1
  1. 1 University of Cambridge
  2. 2 NeuroRx Research, Québec, Canada
  3. 3 Montréal Neurological Institute, McGill University, Montréal, Québec, Canada
  4. 4 University Medical Centre, Amsterdam, The Netherlands
  5. 5 Vita-Salute San Raffaele University, Milan, Italy
  6. 6 Heinrich-Heine University, Düsseldorf, Germany
  7. 7 First Medical Faculty, Charles University in Prague, Czech Republic
  8. 8 Medical University of Łódź, Poland
  9. 9 Sanofi Genzyme
  10. 10 Neuroimmunology and Multiple Sclerosis Research, University Hospital Zurich and University of Zurich

Abstract

Patients with active relapsing-remitting MS (RRMS) who were treatment-naive (CARE-MS I; NCT00530348) or with inadequate response (≥1 relapse) to prior therapy (CARE-MS II; NCT00548405) demonstrated improved efficacy with alemtuzumab versus subcutaneous interferon beta-1a over 2 years, including slowing of brain volume loss (BVL). Here we examine alemtuzumab's effect on BVL over 5 years. Patients who received alemtuzumab at baseline and Month 12 in the core studies could enter an ongoing extension (NCT00930553), receiving as-needed alemtuzumab retreatment for disease activity. MRI scans were acquired at baseline and annually. BVL was measured by relative brain parenchymal fraction change. 349 (95%) CARE-MS I and 393 (93%) CARE-MS II alemtuzumab patients entered the extension. Of those, 68% and 60% received no alemtuzumab since Month 12; 98% and 92% received no other disease-modifying therapy. Median yearly BVL decreased over 4 years in CARE-MS I, remaining low in Year 5 (Year 1: −0.59%, Year 2: −0.25%, Year 3: −0.19%, Year 4: −0.15%, Year 5: −0.20%). The pattern was similar in CARE-MS II (Year 1: −0.48%, Year 2: −0.22%, Year 3: −0.10%, Year 4: −0.19%, Year 5: −0.07%). Slowing of BVL with alemtuzumab was maintained over 5 years, despite most patients not receiving treatment for 4 years.

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.