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Research paper
Time to recanalisation in patients with cerebral venous thrombosis under anticoagulation therapy
  1. Antonio Arauz1,
  2. Juan-Camilo Vargas-González1,
  3. Nayelli Arguelles-Morales1,
  4. Miguel A Barboza1,
  5. Juan Calleja1,
  6. Elizabeth Martínez-Jurado1,
  7. Angélica Ruiz-Franco1,
  8. Alejandro Quiroz-Compean1,
  9. José G Merino2
  1. 1Stroke Clinic, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, México City, Mexico
  2. 2Neurology Department, Johns Hopkins Community Physicians, Bethesda, Maryland, USA
  1. Correspondence to Dr Antonio Arauz, Stroke Clinic, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Insurgentes Sur 3888, Colonia la Fama, México City, DF 14269, Mexico; antonio.arauz{at}prodigy.net.mx

Abstract

Background and purpose Few studies have investigated the rates of recanalisation after cerebral venous thrombosis (CVT). Our objective was to investigate the recanalisation rate and to identify predictors of recanalisation in patients with CVT.

Methods We included 102 patients with confirmed first-ever, non-septic CVT. All patients received anticoagulation for 12 months or until complete recanalisation. To assess recanalisation, patients underwent MR venography every 3 months until partial or complete recanalisation or for 12 months after diagnosis. We conducted two parallel analyses of complete recanalisation versus partial and no recanalisation versus any recanalisation. As a secondary objective we explored the influence of recanalisation on outcome and recurrent events. We calculated the probability of recanalisation using Kaplan-Meier analysis and conducted multivariate analysis using a Cox model.

Results The mean age of patients was 33.5±11 years (80 (78.4%) women). Survival analysis indicated that 50% of the patients had any recanalisation (grades I, II and III) by 64 days and complete recanalisation (grade III) by 169 days. Adjusted Cox proportional model revealed that age <50 years (HR=11.5 95% CI=1.58 to 84.46, p=0.01) and isolated superior sagittal sinus thrombosis (HR=0.39, 95% CI=0.14 to 1.04, p=0.05) predict complete recanalisation, while age <50 years (HR=4.79; 95% CI=1.69 to 13.5, p=0.003) predicts any recanalisation. Patients with complete recanalisation had a greater chance of good functional outcome (HR=5.17; 95% CI=2.8 to 9.53, p<0.001).

Conclusions We found that recanalisation occurs over time, until month 11. Complete recanalisation may influence functional outcome.

  • CEREBROVASCULAR DISEASE

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