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Research paper
Vestibular vertigo and comorbid cognitive and psychiatric impairment: the 2008 National Health Interview Survey
  1. Robin T Bigelow1,
  2. Yevgeniy R Semenov1,
  3. Sascha du Lac1,2,
  4. Howard J Hoffman3,
  5. Yuri Agrawal1
  1. 1Department of Otolaryngology–Head & Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
  2. 2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
  3. 3Epidemiology and Statistics Program, Division of Scientific Programs, National Institute on Deafness and Other Communication Disorders (NIDCD), National Institutes of Health (NIH), Bethesda, Maryland, USA
  1. Correspondence to Robin T Bigelow, Department of Otolaryngology–Head & Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; rbigelow{at}jhmi.edu

Abstract

Background/aims Patients with vestibular disease have been observed to have concomitant cognitive and psychiatric dysfunction. We evaluated the association between vestibular vertigo, cognitive impairment and psychiatric conditions in a nationally representative sample of US adults.

Methods We performed a cross-sectional analysis using the 2008 National Health Interview Survey (NHIS), which included a Balance and Dizziness Supplement, and questions about cognitive function and psychiatric comorbidity. We evaluated the association between vestibular vertigo, cognitive impairment (memory loss, difficulty concentrating, confusion) and psychiatric diagnoses (depression, anxiety and panic disorder).

Results We observed an 8.4% 1-year prevalence of vestibular vertigo among US adults. In adjusted analyses, individuals with vestibular vertigo had an eightfold increased odds of ‘serious difficulty concentrating or remembering’ (OR 8.3, 95% CI 4.8 to 14.6) and a fourfold increased odds of activity limitation due to difficulty remembering or confusion (OR 3.9, 95% CI 3.1 to 5.0) relative to the rest of the US adults. Individuals with vestibular vertigo also had a threefold increased odds of depression (OR 3.4, 95% CI 2.9 to 3.9), anxiety (OR 3.2, 95% CI 2.8 to 3.6) and panic disorder (OR 3.4, 95% CI 2.9 to 4.0).

Conclusions Our findings indicate that vestibular impairment is associated with increased risk of cognitive and psychiatric comorbidity. The vestibular system is anatomically connected with widespread regions of the cerebral cortex, hippocampus and amygdala. Loss of vestibular inputs may lead to impairment of these cognitive and affective circuits. Further longitudinal research is required to determine if these associations are causal.

  • VERTIGO
  • COGNITION
  • DEPRESSION
  • PSYCHIATRY

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