B17 Blood transcriptome replicates dysregulation found in human huntington’s disease brain and shares an immune signature with alzheimer’s disease

Michael Flower; Davina Hensman Moss; Kitty K Lo; James Miller; Gert-Jan van Omen; Peter AC ’t Hoen; Timothy Stone; Amelia Guinee; Doug Langbehn; Lesley Jones; Vincent Plagnol; Willeke MC van Roon-Mom; Peter Holmans; Sarah J Tabrizi

doi:10.1136/jnnp-2016-314597.48

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Pathogenic Mechanisms

B17 Blood transcriptome replicates dysregulation found in human huntington’s disease brain and shares an immune signature with alzheimer’s disease

Authors

Michael Flower 1Department of Neurodegenerative Disease, University College London Institute of Neurology, London, UK PubMed articles Google scholar articles
Davina Hensman Moss 1Department of Neurodegenerative Disease, University College London Institute of Neurology, London, UK PubMed articles Google scholar articles
Kitty K Lo 2University College London Genetics Institute, University College London, London, UK PubMed articles Google scholar articles
James Miller 1Department of Neurodegenerative Disease, University College London Institute of Neurology, London, UK PubMed articles Google scholar articles
Gert-Jan van Omen 3Department of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands PubMed articles Google scholar articles
Peter AC ’t Hoen 3Department of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands PubMed articles Google scholar articles
Timothy Stone 4MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, UK PubMed articles Google scholar articles
Amelia Guinee 5Faculty of Education, University of Cambridge, Cambridge UK PubMed articles Google scholar articles
Doug Langbehn 6Departments of Psychiatry and Biostatistics, University of Iowa, IA, USA PubMed articles Google scholar articles
Lesley Jones 4MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, UK PubMed articles Google scholar articles
Vincent Plagnol 2University College London Genetics Institute, University College London, London, UK PubMed articles Google scholar articles
Willeke MC van Roon-Mom 3Department of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands PubMed articles Google scholar articles
Peter Holmans 4MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, UK PubMed articles Google scholar articles
Sarah J Tabrizi 1Department of Neurodegenerative Disease, University College London Institute of Neurology, London, UK PubMed articles Google scholar articles

Citation

Flower M, Moss DH, Lo KK, et al

B17 Blood transcriptome replicates dysregulation found in human huntington’s disease brain and shares an immune signature with alzheimer’s disease

Journal of Neurology, Neurosurgery & Psychiatry 2016;87:A15.

Publication history

First published September 13, 2016.

Online issue publication

February 21, 2018

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