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D24 Intact emotional impulsivity in huntington’s disease despite altered structural connectivity in the uncinate fasciculus
  1. Silvia Marco-Garcia1,2,
  2. Clara Garcia-Gorro1,2,
  3. Joan Orpella-Garcia1,2,
  4. Nadia Rodriguez-Dechicha3,
  5. Saül Martinez-Horta4,
  6. Irene Vaquer3,
  7. Matilde Calopa5,
  8. Jesus Perez4,
  9. Esteban Muñoz6,7,
  10. Pilar Santacruz6,
  11. Jesus M Ruiz8,
  12. Celia Mareca8,
  13. Nuria Caballol9,
  14. Jaime Kulisevsky4,
  15. Susana Subira3,
  16. Ruth de Diego-Balaguer1,2,10,
  17. Estela Camara1,2
  1. 1Cognition and Brain Plasticity Unit, IDIBELL (Institut d’Investigació Biomèdica de Bellvitge), L’Hospitalet de Llobregat (Barcelona), Spain
  2. 2Basic Psychology Department, Universitat de Barcelona, Barcelona, Spain
  3. 3Fundació Sociosanitària de Barcelona. Hospital Duran i Reynals, Hospitalet de Llobregat (Barcelona), Spain
  4. 4Unitat de Trastorns de Moviment. Departament de Neurologia. Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
  5. 5Hospital Universitari de Bellvitge, L’Hospitalet de Llobregat (Barcelona), Spain
  6. 6IDIBAPS (Institut d’Investigacions Biomèdiques August Pi i Sunyer), Barcelona, Spain
  7. 7Hospital Clínic, Barcelona, Spain
  8. 8Hospital Mare de Deu de la Mercè, Barcelona, Spain
  9. 9Hospital de Sant Joan Despí Moisès Broggi, Sant Joan Despí (Barcelona) Spain
  10. 10ICREA (Catalan Institute for Research and Advanced Studies), Barcelona, Spain

Abstract

Background Impulsivity in Huntington’s disease (HD) patients has been understudied despite its clear impact in daily life. Although it is known that there are different types of impulsivity, this trait has been mainly studied through impulsive actions in cued go/no-go tasks that contain an important motor component, while the more purely emotional/choice component of impulsivity in HD remains unknown.

Objective To study the neurobiological basis that characterise individual differences in emotional impulsivity in HD.

Methods Thirty-one controls and 32 HD patients (11 of which were pre-symptomatic) were scanned using diffusion tensor imaging (DTI) to study the relationship between the structural connectivity of the uncinate fasciculus (UF), the main tract involved in the motivational circuit, and the impulsivity trait (k), evaluated with a delay discounting task.

Results No significant difference was observed in k between the two groups. In controls, k correlated with both right and left UF, whereas in HD patients, k correlated only with the left UF. On the other hand, only the right UF was found to be affected in HD patients compared with controls.

Conclusion This study reveals that HD patients do not differ from controls in the impulse behaviour associated with delay discounting choices. Moreover, the connectivity pattern observed in HD patients and controls is consistent with previous studies that show that individual differences in microstructure integrity of the left UF are related to impulsivity levels in delay discounting tasks.

  • Impulsivity
  • delay discounting
  • structural connectivity
  • DTI

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