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H5 Calf circumference and body composition in huntington’s disease
  1. Jéssica Rivadeneyra1,
  2. Esther Cubo2,
  3. Sara Calvo1,
  4. Natividad Mariscal2,
  5. María Acera3,
  6. Juan Gómez3,
  7. Koldo Berganzo3
  1. 1Unidad de Investigación, Hospital Universitario de Burgos, Burgos, Spain
  2. 2Servicio de Neurología, Hospital Universitario de Burgos, Burgos, Spain
  3. 3Servicio de Neurología, Hospital Universitario Cruces, Barakaldo, Bizkaia, Spain

Abstract

Background Patients with HD are at risk of malnutrition due to increased energy consumption; chorea; alteration in chewing, swallowing, mobility and cognitive functions; but on the other hand they are usually treated with antipsychotic drugs implicated as a risk factor for the development of obesity and metabolic syndrome. Bioelectrical Impedance Assessment (BIA) is a good method for body compartments estimates, but on the other hand anthropometric methods could be cheaper.

Aims To validate anthropometrics as a cheaper method compared to BIA to predict risk for malnutrition in HD in terms of body fat mass, fat free mass in patients with HD.

Methods Multicentric cross-sectional study. Patients with genetically confirmed HD were included. Body composition was measured using the single-frequency (BIA) Tanita® BC418MA, and anthropometric methods (height, calf circumference, and waist circumference) were measured using a soft nonstretchable tape midway.

Results Thirty HD patients with 53% women and a mean age of 57 ± 13 years, BMI 24.1 ± 4.2, waist 86.8 ± 14.3 cm, waist to height ratio 0.53 ± 0.08 were included. According to the WHO classification, 10% of patients were underweighted, 50% normal, 27% overweighted, and 13% obese. Fat free mass was highly correlated with calf circumference (rs = 0.78, p < 0.0001) and moderately correlated with BMI (rs = 0.44, p < 0.023).

Conclusions Anthropometric measures such as calf circumference are highly correlated with fat free mass and can be used as a biomarker. In HD patients, low muscle mass is associated with deterioration of physical function. Further studies are needed to confirm our results.

Acknowledgement We gratefully acknowledge to Gerencia Regional de Salud of Junta de Castilla y León for financial support to this work.

  • Fat free mass
  • BMI and
  • calf circumference

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