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Research paper
Pallidal deep brain stimulation for dystonia: a long term study
  1. Sara Meoni1,2,
  2. Valérie Fraix1,
  3. Anna Castrioto1,
  4. Alim Louis Benabid1,
  5. Eric Seigneuret1,
  6. Laurent Vercueil1,
  7. Pierre Pollak1,3,
  8. Paul Krack1,3,
  9. Eric Chevrier1,
  10. Stephan Chabardes1,
  11. Elena Moro1
  1. 1 Division of Neurology, CHU of Grenoble, Grenoble Alpes University, Grenoble, France
  2. 2 Division of Neurology, A.O.U.C., University of Florence, Florence, Italy
  3. 3 Department of Neurology, University Hospital of Geneva, Geneva, Switzerland
  1. Correspondence to Dr Elena Moro, Service de Neurologie Centre Hospitalier Universitaire de Grenoble BP217 38043 Grenoble CEDEX 09 France; elenamfmoro{at}gmail.com

Abstract

Background Pallidal deep brain stimulation (globus pallidus internus (GPi) DBS) is the best therapeutic option for disabling isolated idiopathic (IID) and inherited (INH) dystonia. Acquired dystonia (AD) may also benefit from GPi DBS. Efficacy and safety in the long-term remained to be established.

Objective To retrospectively assess long-term clinical outcomes and safety in dystonic patients who underwent GPi DBS.

Methods Patients were videotaped and assessed preoperatively and postoperatively (1-year and at last available follow-up) using the Burke-Fahn-Marsden Dystonia Rating Scale (motor score (BFMDRS-M); disability score (BFMDRS-D)).

Results Sixty-one patients were included (follow-up 7.9±5.9 years; range 1–20.7). In IID and INH (n=37), the BFMDRS-M improved at first (20.4±24.5; p<0.00001) and last (22.2±18.2; p<0.001) follow-ups compared with preoperatively (50.5±28.0). In AD (n=19), the BFMDRS-M ameliorated at 1-year (40.8±26.5; p<0.02) and late follow-ups (44.3±24.3; p<0.04) compared with preoperatively (52.8±24.2). In INH dystonia with other neurological features (n=4) there was no motor benefit. In IID and INH, the BFMDRS-D improved at 1-year (9.5±7.5; p<0.0002) and late follow-ups (10.4±7.8; p<0.016) compared with preoperatively (13.3±6.9). In AD, the BFMDRS-D reduced at 1-year (12.0±8.1; p<0.01) and late follow-ups (12.7 ±6.1; p=0.2) compared with preoperatively (14.35±5.7). Most adverse events were hardware related.

Conclusions GPi DBS is an effective and safe treatment in most patients with dystonia.

  • deep brain stimulation
  • dystonia
  • globus pallidus
  • motor outcome

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Footnotes

  • Handling editor Matthew C. Kiernan

  • Contributors SM: conception and design of the study, acquisition of data and analysis and interpretation of data, and drafting the article. All the other authors made a critical review of the article and the final approval of the version to be submitted.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval Ethics Review Board of the Grenoble University Hospital.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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